![]() ![]() If skin infections are present or develop, an appropriate antifungal, antibacterial or antiviral agent should be used. Signs and symptoms of glucocorticosteroid insufficiency may occur, requiring supplemental systemic corticosteroids. If HPA-axis suppression is noted, the frequency of application should be reduced or the drug should be withdrawn, or a less potent corticosteroid should be substituted. Minimize systemic corticosteroid effects by mitigating the risk factors for increased systemic absorption and using Locoid Lipocream as recommended. This may be done by using cosyntropin (ACTH 1-24) stimulation testing (CST). Patients applying a topical corticosteroid to a large surface area or to areas under occlusion should be considered for periodic evaluation of the HPA axis. Pediatric patients may be more susceptible than adults to systemic toxicity from equivalent doses of Locoid Lipocream due to their larger skin-surface-to-body-mass ratios. Studies conducted in pediatric subjects demonstrated reversible HPA-axis suppression after use of Locoid Lipocream. Systemic effects of topical corticosteroids may include reversible HPA-axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria. Warnings and Precautions Hypothalamic-Pituitary-Adrenal (HPA) Axis Suppression Locoid Lipocream is supplied in tubes of 45 g and 60 g. Each gram of Locoid Lipocream contains 1 mg of hydrocortisone butyrate in a white to off-white hydrophilic cream base. ![]() Related/similar drugs prednisone, hydroxyzine, methotrexate, dexamethasone, Benadryl, hydrocortisone topical, diphenhydramine Dosage Forms and StrengthsĬream, 0.1%. Locoid Lipocream is not for oral, ophthalmic, or intravaginal use. Avoid use in the diaper area, as diapers or plastic pants may constitute occlusive dressings. ĭo not use Locoid Lipocream with occlusive dressings unless directed by a physician. The safety and efficacy of Locoid Lipocream has not been established beyond 4 weeks of use. Before prescribing for more than 2 weeks, any additional benefits of extending treatment to 4 weeks should be weighed against the risk of HPA-axis suppression and local adverse events. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary. Do not apply Locoid Lipocream in the diaper area unless directed by a physician.ĭiscontinue therapy when control is achieved. Locoid Lipocream Dosage and Administrationįor corticosteroid-responsive dermatoses in adults, apply a thin layer to the affected skin areas 2 or 3 times daily, depending on the severity of the condition, and rub in gently.įor atopic dermatitis in patients 3 months to 18 years of age, apply a thin layer to the affected skin areas 2 times daily and rub in gently. The topical treatment of mild to moderate atopic dermatitis in pediatric patients 3 months to 18 years of age.Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in adults.Expand Indications and Usage for Locoid Lipocream ![]()
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